Please use this identifier to cite or link to this item: http://159.69.53.182:8080/xmlui/handle/123456789/429
Title: LMP-1 IMMUNOHISTOCHEMICAL DETECTION OF EPSTEIN - BARR VIRUS IN LYMPHOMA AMONG SUDANESE PATIENTS
Other Titles: LMP-1 IMMUNOHISTOCHEMICAL DETECTION OF EPSTEIN - BARR VIRUS IN LYMPHOMA AMONG SUDANESE PATIENTS
Authors: Yousif Elemam, Ibrahim Bakhit
Keywords: Epstein-Barr virus, malignant lymphomas, lymph node hyperplasia, Hodgkin’s disease, Immunohistochemistry, Sudan.
Sudan
Epstein-Barr virus
malignant lymphomas
lymph node hyperplasia
Hodgkin’s disease
Immunohistochemistry
Issue Date: 1-Sep-2015
Publisher: International Journal of Research Granthaalayah
Citation: LMP-1 IMMUNOHISTOCHEMICAL DETECTION OF EPSTEIN - BARR VIRUS IN LYMPHOMA AMONG SUDANESE PATIENTS
Series/Report no.: Yousif et. al., Vol.3;(Iss.9)
Abstract: Several studies have suggested a probable etiologic association between Epstein-Barr virus (EBV) and lymphoma; multiple EBV proteins can be expressed in infected lymphocytes, among which Latent membrane protein-1(LMP-1) is thought to be most important for malignant transformation, the aim of this study was to investigate the association of LMP-1 EBV in this tumors. This study was carried at the Radio Isotope Center Khartoum (RICK)- Khartoum state –Sudan from January 2015 to July 2015, it was retrospective and prospective, the study include ninety (90) Formalin –fixed paraffin embedded biopsies from which seventy (70) of malignant lymphoma (study group) and twenty (20) lymph node hyperplasia (control group ). EBV was detected in (32%) (23/70), and (10%) (2/20) respectively, the (P.value =0.04), this result showed a significant difference between case and control groups, the, there is no statistically significant difference between the two lymphoma subtypes Hodgkin's and Non-Hodgkin`s the (P.value= 0.333). There is sufficient evidence for the carcinogenicity of EBV in the causation of lymphoma in Sudan. This requires further evaluation to find out whether this positivity is due to co-infection or has a role in pathogenesis.
Description: Cite This Article: Ibrahim Bakhit Yousif , Yousif Mohammed Yousif, and Mohammed Sideeg Abd Elaziz, “LMP-1 IMMUNOHISTOCHEMICAL DETECTION OF EPSTEIN - BARR VIRUS IN LYMPHOMA AMONG SUDANESE PATIENTS” International Journal of Research – Granthaalayah, Vol. 3, No. 9(2015): 63-69.
URI: http://hdl.handle.net/123456789/429
ISSN: ISSN- 2350-0530(O)
2394-3629(P)
Appears in Collections:Researches and Scientific Papers البحوث والأوراق العلمية

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