IDENTIFICATION OF HUMAN PAPILLOMAVIRUS IN ESOPHAGEAL CANCER IN SUDAN

Abstract

Background: Esophageal cancer, mostly squamous cell carcinomas, is the eight most common cancers worldwide. There are a number of suspected genetic or environmental etiologies. Human papilloma virus (HPV) is said to be a major etiology in areas with high incidence of esophageal carcinoma. This study was designed to investigate the presence of HPV in esophageal cancer in Sudan. Methods: A total of 102 formalin fixed paraffin embedded blocks previously diagnosed as esophageal cancers were tested by immunohistochemistry for HPV 16/18. SPSS version 11.5 computer programs were used to analyze the data, frequencies, and means, the P.value was calculated by Chi square test. Results: This analysis included 102 patients with esophageal cancer were included in this study (55% male and 45% female), their age ranging from 21to 98 years with mean age of 59.0 years old, squamous cell carcinoma comprised (89%), while (11%) is adenocarcinoma, HPV was detected in HPV was 13.7 0% without statistically significant differences between squamous and adenocarcinoma. Conclusions: HPV infection may be one of many factors contributing to development of esophageal cancer.