Please use this identifier to cite or link to this item: http://repository.ush.edu.sd:8080/xmlui/handle/123456789/444
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dc.contributor.authorYousif Elemam, Ibrahim Bakhit-
dc.contributor.authorMansour, Moneira A.-
dc.contributor.authorM. Elhassan, Mogahid-
dc.contributor.authorM. Eltom, Faris-
dc.contributor.authorYousif, Hala M.-
dc.contributor.authorHashim, M. Missawi-
dc.contributor.authorMohamed, Eshraga O.-
dc.contributor.authorFarsi, Bahjat S.-
dc.date.accessioned2018-05-21T11:29:51Z-
dc.date.available2018-05-21T11:29:51Z-
dc.date.issued2017-12-
dc.identifier.issn1996-0808-
dc.identifier.urihttp://hdl.handle.net/123456789/444-
dc.descriptionVol. 11(48), pp. 1693-1698, 28 December, 2017 DOI: 10.5897/AJMR2017.8763 Article Number: 633317755615 ISSN 1996-0808 Copyright © 2017 Author(s) retain the copyright of this article http://www.academicjournals.org/AJMRen_US
dc.description.abstractOne of the important causes of uterine and cervical malignancy and premalignancy lesions in human is the infection with papilloma virus, especially genotypes that belong to high-risk human papilloma virus (HR-HPV) group. The involvement of HPV DNA testing in an adjacent to cytological screening will be of positive impact in early discovery of cervical neoplasia among women at risk and will significantly minimize the mortality rate. The study subjects were screened for cervical neoplasia which may be caused by different genotypes of HR-HPV among Saudi females. Two hundred and thirty eight (n=238) cervical scrapings were collected from women who attended Maternity and Children Hospital (MCH) at Al-Madinah Al Munawarah between August 2015 to January 2017, and thereafter processed and examined cytologicaly using liquid based cytology (LBC). Simultaneously, one-step Polymerase chain reaction (PCR) was performed to examine the presence of HR-HPV different genotypes. Low incidence of precancerous epithelial lesions was observed among enrolled patients 13 (5.5%) with the following distribution: high-grade squamous intraepithelial lesion in 5 cases (38.5%), low-grade squamous intraepithelial lesion in 4 (30.8%) and four cases (30.8%) as a typical squamous cells of undetermined significance. Nevertheless, HR-HPV was detected only in 6 (2.5%) cases and overall prevalence of HRHPV in abnormal Pap smears was 15.4% (2/13). On the other hand, HPV were also seen in 1.9% (4/238) among smears that were registered free from any type of malignancy (NILM). The study concluded very low prevalence of HR-HPV in routine cervical screening samples among suspected Saudi women. Additionally, weak correlation between HPV and the incidence of cervical neoplasia was also observed. This may direct the clinicians and researchers to look for other suspected HPV genotypes in this regards.en_US
dc.language.isoen_USen_US
dc.publisherAfrican Journal of Microbiology Researchen_US
dc.subjectCervical canceren_US
dc.subjectcanceren_US
dc.subjectCervicalen_US
dc.subjecthigh-risk human papilloma virusen_US
dc.subjecthigh-risken_US
dc.subjecthuman papillomaen_US
dc.subjectpapillomaen_US
dc.subjecthumanen_US
dc.subjectvirusen_US
dc.subjectpapilloma virusen_US
dc.subjectHR-HPVen_US
dc.subjectlow-risk human papilloma virus (HRHPV)en_US
dc.subjectHRHPVen_US
dc.subjectSaudi womenen_US
dc.subjectAl-Madinah Al Munawarahen_US
dc.subjectSaudi Arabiaen_US
dc.titleGenotyping of high-risk human papilloma virus (HRHPV) and its role in cervical cancer among suspected women at reproductive ageen_US
dc.typeArticleen_US
Appears in Collections:Researches and Scientific Papers البحوث والأوراق العلمية



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