Clinical and pathological factors predicting axillary nodal metastasis in breast cancer patients of central Sudan: A single institution experience

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dc.contributor.author Mohanned, Omer Abass
dc.contributor.author Mohamed, Daffalla Awadalla Gismalla
dc.contributor.author Moawia, Mohamed Ali Elhassan
dc.date.accessioned 2020-12-29T14:06:05Z
dc.date.available 2020-12-29T14:06:05Z
dc.date.issued 2019-12
dc.identifier.citation Gismalla MD, Elhassan MM, Abass MO. Clinical and pathological factors predicting axillary nodal metastasis in breast cancer patients of central Sudan: A single institution experience. Saudi J Health Sci 2019;8:146-50. Mohamed Daffalla Awadalla Gismalla, Moawia Mohamed Ali Elhassan1, Mohanned Omer Abass en_US
dc.identifier.other DOI: 10.4103/sjhs.sjhs_90_19
dc.identifier.uri http://www.saudijhealthsci.org
dc.identifier.uri http://hdl.handle.net/123456789/1124
dc.description Background: Data on factors predicting axillary lymph node (ALN) metastasis among Sudanese patients with breast cancer are rare. Aim: The aim of this study is to provide baseline information of the clinical and pathological factors predicting ALN metastasis in patients who underwent modified radical mastectomy or breast conserving surgery at Wad-Madani Teaching Hospital, Sudan. Materials and Methods: We performed a prospective study to examine the correlation between ALN status and clinicopathological characteristics of 81 patients with breast cancer. Results: The median age at diagnosis was 47 years (range, 25–85 years). The median number of lymph nodes (LNs) retrieved was 14 (range 2–31). ALNs containing metastases were found in 52 patients (64.2%); more than half of them (n = 30) had three or more positive LNs. Factors associated with lower chance of developing LN metastasis were age more than 60 years, postmenopausal status, smaller tumor size, and tumor that were positive for estrogen receptor and/or progesterone receptor. The number of ALNs retrieved was the only factor which showed statistically significant association with ALNs metastases. Conclusions: Our finding reveals a high incidence of ALN metastasis among patients with breast cancer in Sudan, which is likely due to various factors such as young age at diagnosis and large tumor size as a result of late diagnosis. Key words: Breast cancer, lymph node, sub-Saharan Africa, Sudan en_US
dc.description.abstract Background: Data on factors predicting axillary lymph node (ALN) metastasis among Sudanese patients with breast cancer are rare. Aim: The aim of this study is to provide baseline information of the clinical and pathological factors predicting ALN metastasis in patients who underwent modified radical mastectomy or breast conserving surgery at Wad-Madani Teaching Hospital, Sudan. Materials and Methods: We performed a prospective study to examine the correlation between ALN status and clinicopathological characteristics of 81 patients with breast cancer. Results: The median age at diagnosis was 47 years (range, 25–85 years). The median number of lymph nodes (LNs) retrieved was 14 (range 2–31). ALNs containing metastases were found in 52 patients (64.2%); more than half of them (n = 30) had three or more positive LNs. Factors associated with lower chance of developing LN metastasis were age more than 60 years, postmenopausal status, smaller tumor size, and tumor that were positive for estrogen receptor and/or progesterone receptor. The number of ALNs retrieved was the only factor which showed statistically significant association with ALNs metastases. Conclusions: Our finding reveals a high incidence of ALN metastasis among patients with breast cancer in Sudan, which is likely due to various factors such as young age at diagnosis and large tumor size as a result of late diagnosis. Key words: Breast cancer, lymph node, sub-Saharan Africa, Sudan en_US
dc.description.sponsorship Shendi University en_US
dc.language.iso en_US en_US
dc.publisher Saudi Journal for Health Sciences - Published by Wolters Kluwer - Medknow en_US
dc.relation.ispartofseries Volume 8;146-50
dc.subject Breast en_US
dc.subject Breast Cancer en_US
dc.subject lymph node en_US
dc.subject sub-Saharan Africa en_US
dc.subject Sudan en_US
dc.title Clinical and pathological factors predicting axillary nodal metastasis in breast cancer patients of central Sudan: A single institution experience en_US
dc.type Article en_US


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