Abstract:
Abstract
Obesity is a major health problem in this century, and is associated with many endocrine disorders
and metabolic diseases.
It was reported that obesity is associated with male infertility anddecreased testosterone and increased
estradiol level.
Testosterone (C19H28O2) is the most important androgen in potency and quantity and required in
high testicular concentration for spermatogenesis.
Objectives
The study aimed to examine the association between obesity and serum total testosterone level in
middle-aged healthy Sudanese men.
Methods
It was a cross sectional, descriptive, case control study; conducted in Shendi town, River Nile
State,north Sudan from April 2018 to August 2018. It included sixtymiddle aged healthy Sudanese
men.Twenty of them were normal (BMI ≤25). Twenty were overweight (BMI ≥25) and twenty were
obese (BMI ≥30), Testosterone level was measured by ELISA technique and its concentration was
expressed as ng/ml.
Result
The study revealed significant inverse correlation of serum total testosteronewith BMI(r = - 0.787, P
value = 0.000), waist circumference (WC) (r = - 0.717, P value = 0.000) and waist to hip ratio (WHR)
(r = - 0.580, P value = 0.000).
The study also found insignificant relationship between age and serum total testosterone level with (P
value = 0.061). It also demonstrated statistically significant decreased of serum total testosterone
level with smoking with (P. value = 0.017).
Keywords: Obesity, BMI, WC, WHR, Testosterone, Fertility, Smoking
Description:
Abstract
Obesity is a major health problem in this century, and is associated with many endocrine disorders
and metabolic diseases.
It was reported that obesity is associated with male infertility anddecreased testosterone and increased
estradiol level.
Testosterone (C19H28O2) is the most important androgen in potency and quantity and required in
high testicular concentration for spermatogenesis.
Objectives
The study aimed to examine the association between obesity and serum total testosterone level in
middle-aged healthy Sudanese men.
Methods
It was a cross sectional, descriptive, case control study; conducted in Shendi town, River Nile
State,north Sudan from April 2018 to August 2018. It included sixtymiddle aged healthy Sudanese
men.Twenty of them were normal (BMI ≤25). Twenty were overweight (BMI ≥25) and twenty were
obese (BMI ≥30), Testosterone level was measured by ELISA technique and its concentration was
expressed as ng/ml.
Result
The study revealed significant inverse correlation of serum total testosteronewith BMI(r = - 0.787, P
value = 0.000), waist circumference (WC) (r = - 0.717, P value = 0.000) and waist to hip ratio (WHR)
(r = - 0.580, P value = 0.000).
The study also found insignificant relationship between age and serum total testosterone level with (P
value = 0.061). It also demonstrated statistically significant decreased of serum total testosterone
level with smoking with (P. value = 0.017).
Keywords: Obesity, BMI, WC, WHR, Testosterone, Fertility, Smoking
