Assessment of Proliferation Activity by Using Nucleolar Organiser Regions Count among Sudanese Patients with Prostate Cancer and Benign Prostate Hyperplasia

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dc.contributor.author Yousif Elemam, Ibrahim Bakhit
dc.contributor.author Elsheikh, Mohammed Abdalgadir
dc.contributor.author Mohammed Ali Elnour, Areeg
dc.contributor.author Abd Elhaleem, Habiba Mohieldeen Mohammed
dc.contributor.author Alobaid, Awad Eljeed Abugooda
dc.date.accessioned 2018-05-21T10:33:37Z
dc.date.available 2018-05-21T10:33:37Z
dc.date.issued 2015-11-16
dc.identifier.citation Ibrahim Bakhit Yousif Elemam, Mohammed Abdalgadir Elsheikh, Areeg Mohammed Ali Elnour, Habiba Mohieldeen Mohammed Abd Elhaleem, Awad Eljeed Abugooda Alobaid. Assessment of proliferation activity by using nucleolar organiser regions count among sudanese patients with prostate cancer and benign prostate hyperplasia. J Pharm Biomed Sci 2015;05(11):863–866. en_US
dc.identifier.issn 2230-7885
dc.identifier.uri http://hdl.handle.net/123456789/436
dc.description.abstract Background Prostatic adenocarcinoma is the most prevalent cancer and the second cause of cancer related death among men; the tumour proliferative activity is difficult to measure histologically. Increasing evidence suggests that the factors controlling cell cycle progression also modulate the rate of ribosome biogenesis; and can assess the proliferative activity. The present study aimed to assess the proliferation activity in prostate cancer. Materials and Methods A total of 40 various prostatic lesions were studied, 20 cases of prostatic adenocarcinomas (study group) and 20 cases of benign prostatic hyperplasia (BPH) as (control group). Sections of 3-µ thickness was obtained from each formalin-fixed paraffin-embedded tissue block using rotary microtome and it was stained using haematoxylin and eosin (Mayer’s technique) and AgNOR stains. results The majority of patients with BPH and prostate adenocarcinoma were in their sixth to eighth decade of life. The BPH samples displayed fewer AgNORs (mean 2.0 dots/cell) compare to adenocarcinomas (mean 4.1 dots/cell), p value was (0.001). Therefore this data indicate that analysis of silver staining-positive material in intact interphase cells may help distinguish between benign and malignant prostatic tumours. conclusions AgNOR have a value in distinguishing between BPH and adenocarcinoma of the prostate. en_US
dc.description.sponsorship Shendi Unviersity en_US
dc.language.iso en_US en_US
dc.publisher JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL SCIENCES en_US
dc.relation.ispartofseries Sci 2015;05;(11):863–866.
dc.subject prostate en_US
dc.subject carcinoma en_US
dc.subject prostatic hyperplasia en_US
dc.subject AgNORs en_US
dc.title Assessment of Proliferation Activity by Using Nucleolar Organiser Regions Count among Sudanese Patients with Prostate Cancer and Benign Prostate Hyperplasia en_US
dc.type Article en_US


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