IMMUNOHISTOCHEMICAL SCREENING FOR HUMAN PAPILLOMA VIRUS AMONG SUDANESE PATIENTS WITH NASOPHARYNGEAL CARCINOMA

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dc.contributor.author Yousif Elemam, Ibrahim Bakhit
dc.date.accessioned 2018-05-21T11:04:44Z
dc.date.available 2018-05-21T11:04:44Z
dc.date.issued 2016
dc.identifier.citation ejbps, 2016, Volume 3, Issue 2, 100-103 en_US
dc.identifier.issn 2349-8870
dc.identifier.uri http://hdl.handle.net/123456789/440
dc.description.abstract Background: Nasopharyngeal carcinoma (NPC) is a malignant tumor which arises in surface epithelium of the posterior wall of the nasopharynx. Epstein-Barr virus (EBV) is a well known causative agent for this tumour; recent reports have implicated oncogenic Human Papillomavirus (HPV) in a subgroup of these tumours. The aim of this study was to screen for the presence of HPV in (NPC) in Sudan. Methods and Materials; Paraffinembedded tumor specimens from 30 patients with NPC were screened for HPV. HPV detection was performed by immunohistochemistry targeting type 6, 11, 16, 18, 31, 33, 42, 51, 52, 56 and 58. Results: Of the 30 cases included in this study, there were 6 (20%) keratinising squamous cell carcinomas (KSCCs), 20 (66.7%) non-keratinising carcinomas, differentiated type (NK-D) and 4(13.3%) non-keratinising carcinomas undifferentiated type (NK-U). HPV was detected in two cases out of thirty (6.6%), this positivity was observed only in non-keratinising carcinomas, differentiated type (NK-D). Conclusion: Our data indicated infection with HPV is rare in NPC, though larger studies are needed to verify these findings. en_US
dc.language.iso en_US en_US
dc.publisher European Journal of Biomedical and Pharmaceutical Sciences en_US
dc.relation.ispartofseries Volume 3;Issue 2, 100-103
dc.relation.ispartofseries ejbps, 2016, Volume 3;Issue 2, 100-103
dc.subject papillomavirus en_US
dc.subject Human papillomavirus en_US
dc.subject human en_US
dc.subject carcinoma en_US
dc.subject Nasopharyngeal en_US
dc.subject Nasopharyngeal carcinoma en_US
dc.title IMMUNOHISTOCHEMICAL SCREENING FOR HUMAN PAPILLOMA VIRUS AMONG SUDANESE PATIENTS WITH NASOPHARYNGEAL CARCINOMA en_US
dc.type Article en_US


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